A FAST PROCEDURE FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES USING POLYMERSUPPORTED WITH TRIFLUOROMETHANESULFONIC ACID AS NOVEL AND REUSABLE CATALYST

17 Downloads

In the last ten years, supported reagents on polymers have become increasingly applied in organic synthesis, because the reactions are carried out with simple work-up, easy product isolation, and mild reaction conditions. Benzimidazole is a kind of substances which have found practical applications in organic synthesis, and the benzimidazole nucleus are found in a variety of pharmaceuticals as cardiotonic agents, potential antitumor poli(ADP-ribose) phosphorilase inhibitors,  Histamine H4 receptor binders, antiparasitic, cardiovascular, anticancers, antimicrobials,  and antihypertensives,. Due to the high importance of 2-aryl-1H-benzimidazoles for the preparation of biologically active molecules, their synthesis has been received considerable attention.

File Name: 1014 PVP-Tf Chilian.pdf
File Size: 431.27 KB
File Type: application/pdf
Hits: 157 Hits
Download: 17 times
Created Date: 05-03-2018
Last Updated Date: 05-03-2018
Document history:

J. Chil. Chem. Soc., 58, Nº 3 (2013)